An Approach to 2,4-Substituted Pyrazolo[1,5-a]pyridines and Pyrazolo[1,5-a]azepines by Ring-Closing Metathesis

作者：Fustero Santos^*; Roman Raquel; Asensio Amparo; Maestro Miguel A; Acena Jose L; Simon Fuentes Antonio

来源：European Journal of Organic Chemistry, 2013, 2013(31): 7164-7174.

DOI：10.1002/ejoc.201300901

• Synthetic methods
• Asymmetric synthesis
• Metathesis
• Peptidomimetics
• Nitrogen heterocycles

The ring-closing metathesis (RCM) reactions of dienylpyrazoles have been employed in the synthesis of pyrazolo[1,5-a]pyridine and pyrazolo[1,5-a]azepine derivatives. Based on this approach, the diastereoselective synthesis of potential peptidomimetics containing four amino acid residues with the second (i+1) and third (i+2) fragments having been substituted by bicyclic frameworks is described.

• 出版日期2013-11