ALLERGIC INFLAMMATION: ROLE OF CYTOKINES WITH SPECIAL EMPHASIS ON IL-4

作者：Saggini A^*; Maccauro G; Tripodi D; De Lutiis M A; Conti F; Felaco P; Fulcheri M; Galzio R; Caraffa A; Antinolfi P; Felaco M; Pandolfi F; Sabatino G; Neri G; Shaik Dasthagirisaheb Y B

来源：International Journal of Immunopathology and Pharmacology, 2011, 24(2): 305-311.

• allergy
• inflammation
• cytokines

This review examines recent articles on the relationship of cytokines to allergy and inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is therefore to review published studies to identify cytokines consistently involved in allergic inflammation. Proinflammatory cytokines, including IL-4, 1L-5, IL-13 and GM-CSF along with TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 and IFN-gamma are deeply involved in the regulation of asthma. Blocking the effect of these proinflammatory cytokines might provide new therapeutic approaches for the control of allergy and inflammation.

• 出版日期2011-6