A Role for Mineralocorticoid Receptors in the Physiology of the Ovine Fetus: Effects on ACTH and Lung Liquid Composition

作者：Keller Wood Maureen^*; Wood Charles E; McCartney Jarret; Jesse Nathan M; Perrone Dana

来源：Pediatric Research, 2011, 69(6): 491-496.

DOI：10.1203/PDR.0b013e318217f4cf

In the human and ovine fetus, the presence of 11 beta-hydroxysteroid dehydrogenase I allows cortisol and other corticosteroids to act at mineralocorticoid receptors (MRs) in lung and brain. To test the physiologic role of MRs in the late gestation fetus, fetal lambs were infused with a specific MR antagonist for 12 h. Infusion of the MR antagonist significantly increased plasma ACTH and cortisol concentrations. Infusion of the MR antagonist also significantly increased fetal PCO(2) and hematocrit, and decreased fetal pH, but did not alter fetal heart rate or blood pressure. Infusion of the MR antagonist altered the ratio of Na(+) to K(+) in lung fluid but did not alter the rate of production of lung liquid or the expression of the epithelial sodium channel a or of the Na,K ATPase alpha 1 in lung. These results suggest that corticosteroids act at MR to regulate ACTH and blood volume and modulate lung fluid composition in the fetus, but basal levels of corticosteroids do not alter lung liquid production rate through effects on MR. (Pediatr Res 69: 491-496, 2011)

• 出版日期2011-6