An Efficient One-Pot Synthesis of N-(1,3-Diphenyl-1H-Pyrazol-5-yl)amides

作者：Su Wei Nien; Lin Tsung Ping; Cheng Kaung Min; Sung Kuan Chin; Lin Shao Kai; Wong Fung Fuh^*

来源：Journal of Heterocyclic Chemistry, 2010, 47(4): 831-837.

DOI：10.1002/jhet.343

A "one-pot" method for the synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides was developed by cyclization of benzoylacetonitrile (1) and phenylhydrazine in neat condition followed by acylation. The corresponding N-(1,3-diphenyl-1H-pyrazol-5-yl)amides were provided in good to excellent yields (70 90%). The significant advantages of the new synthetic method are excellent yields and simple work-up procedure without isolation and purification of intermediary 5-amino-1,3-diphenyl pyrazol (2).

• 出版日期2010-7
• 单位中国医科大学