科研之友
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摘要
A new approach towards the rapid identification of quality binders to cucurbiturils-those that combine high affinity with high selectivity for a particular homologue-was developed. The assay exploits macrocycle-specific optical fingerprints (colorimetric or fluorimetric) of carefully selected indicators dyes. The screening of a guest library revealed known (e.g., adamantane derivatives) and new (e.g., terpenes) quality binders. The predictive power of the assay was underpinned by the modeling of the involved thermodynamic equilibria.
- 出版日期2014-8-4
