Activation-induced cell death in T lymphocytes from multiple sclerosis patients

作者：Moreno Montserrat; Negrotto Laura; Rio Jordi; Moubarak Rana; Martin Isabel; Bustamante Marta F; Comella Joan X; Vidal Jordana Angela; Perez Boza Jennifer; Montalban Xavier; Comabella Manuel^*

来源：Journal of Neuroimmunology, 2014, 272(1-2): 51-55.

DOI：10.1016/j.jneuroim.2014.04.007

• Multiple sclerosis
• Apoptosis
• Activation-induced cell death
• T lymphocytes
• Caspase 3
• Fas

Apoptosis is a major mechanism regulating immune tolerance by the elimination of autoreactive T lymphocytes. A failure of activation induced cell-death (AICD) has been described in T lymphocytes from patients with multiple sclerosis (MS). The aims of this study were to evaluate AICD in T lymphocytes from patients with MS and healthy controls, and to explore the molecular mechanisms underlying the deregulation observed in apoptosis induction. PHA-induced AICD was reduced in T lymphocytes from patients with relapsing-remitting MS compared with controls. This finding was associated with a diminished expression of Fas and a failure in caspase 3 activation.

• 出版日期2014-7-15