A Versatile Total Synthesis of Trachycladines A and B and Their Analogues

作者:Peitsinis Zisis V; Melidou Dafni A; Stefanakis John G; Evgenidou Helen; Koumbis Alexandros E*
来源:European Journal of Organic Chemistry, 2014, 2014(36): 8160-8166.
DOI:10.1002/ejoc.201403091

摘要

The synthesis of marine nucleosides trachycladines A and B and two nucleoside analogues was accomplished following a versatile and high-yielding scheme starting from D-ribose. The key step involved a regio- and stereoselective direct Vorbruggen glycosylation reaction between the appropriate nucleobase and a common intermediate, 2-C-methyl-D-5-deoxyribofuranose triacetate.

  • 出版日期2014-12