A Trimodality Comparison of Volumetric Bone Imaging Technologies. Part II: 1-Yr Change, Long-Term Precision, and Least Significant Change

作者：Wong Andy K O^*; Beattie Karen A; Min Kevin K H; Merali Zamir; Webber Colin E; Gordon Christopher L; Papaioannou Alexandra; Cheung Angela M W; Adachi Jonathan D

来源：Journal of Clinical Densitometry, 2015, 18(2): 260-269.

DOI：10.1016/j.jocd.2014.07.004

• least significant change
• long-term precision
• MRI
• pQCT
• segmentation
• standard error of the estimate

The previous article in this 3-part series demonstrated short-term precision and validity for volumetric bone outcome quantification using in vivo peripheral (p) quantitative computed tomography (pQCT) and magnetic resonance imaging (MRI) modalities at resolutions 200 mu m or higher. However, 1-yr precision error and clinically significant references are yet to be reported for these modalities. This study examined 59 women with mean age of 75 +/- 9 yr and body mass index of 26.84 +/- 4.77 kg/m(2), demonstrating the lowest 1-yr precision error, standard errors of the estimate, and least significant change values for high-resolution (hr) pQCT followed by pQCT, and 1.0-T pMRI for all volumetric bone outcomes except trabecular number. Like short-term precision, 1-yr statistics for trabecular separation were similar across modalities. Excluding individuals with a previous history of fragility fractures, or who were current users of antiresorptives reduced 1-yr change for bone outcomes derived from pQCT and pMR images, but not hr-pQCT images. In Part II of this 3-part series focused on trimodality comparisons of 1-yr changes, hr-pQCT was recommended to be the prime candidate for quantifying change where smaller effect sizes are expected, but pQCT was identified as a feasible alternative for studies expecting larger changes.

• 出版日期2015-6