A simple test for homogeneity of Hardy-Weinberg equilibrium and disequilibrium across strata

作者：Kim Jeongjin; Kwon Hye Soo; Son Mun S; Yang Tae Young^*

来源：Journal of the Korean Statistical Society, 2013, 42(2): 161-168.

DOI：10.1016/j.jkss.2012.07.001

• Exact test
• Hardy-Weinberg disequilibrium
• Hardy-Weinberg equilibrium
• Homogeneity
• SNP
• Strata
• Tippett%26apos
• s minimum p-value method

For an SNP (single-nucleotide polymorphism) sampled from several ethnic populations with different allele frequencies, verifying the homogeneity of Hardy-Weinberg equilibrium or disequilibrium across strata is a critical factor in measuring the quality of the SNP. We obtain a simple unified method that can be applied directly to test the homogeneity of Hardy-Weinberg equilibrium or disequilibrium across strata. The deviation of each ethnic population from homogeneity is measured via a new exact test that depends on a common homogeneity coefficient. Tippett%26apos;s minimum p-value method is then used to test for homogeneity across strata.

• 出版日期2013-6