A discrete approach for modeling cell-matrix adhesions

作者：Escribano J; Sanchez M T; Garcia Aznar J M^*

来源：Computational Particle Mechanics, 2014, 1(2): 117-130.

DOI：10.1007/s40571-014-0006-7

• Acto-myosin contraction
• Discrete model
• Retrograde flow
• Brownian dynamics simulation
• Focal adhesion

During recent years the interaction between the extracellular matrix and the cytoskeleton of the cell has been object of numerous studies due to its importance in cell migration processes. These interactions are performed through protein clutches, known as focal adhesions. For migratory cells these focal adhesions along with force generating processes in the cytoskeleton are responsible for the formation of protrusion structures like lamellipodia or filopodia. Much is known about these structures: the different proteins that conform them, the players involved in their formation or their role in cell migration. Concretely, growth-cone filopodia structures have attracted significant attention because of their role as cell sensors of their surrounding environment and its complex behavior. On this matter, a vast myriad of mathematical models has been presented to explain its mechanical behavior. In this work, we aim to study the mechanical behavior of these structures through a discrete approach. This numerical model provides an individual analysis of the proteins involved including spatial distribution, interaction between them, and study of different phenomena, such as clutches unbinding or protein unfolding.

• 出版日期2014-6