A New and Cost Effective Approach for Simultaneous Voltammetric Analysis of two Related Benzimidazole Drugs and their Determination in Biological Fluids

作者：Khashaba Pakinaz Y; Ali Hassan Refat H; El Wekil Mohamed M^*

来源：Electroanalysis, 2017, 29(6): 1643-1650.

DOI：10.1002/elan.201700078

• Voltammetry
• poly (EBT)
• pencil graphite electrode
• rabeprazole sodium
• domperidone
• biological fluids

A polymerized film of eriochrome black T (EBT) was prepared on the surface of pencil graphite electrode in alkaline solution by cyclic voltammetry. The redox response of the poly (EBT) film at the electrode appeared in a couple of redox peak in 0.1 M sodium hydroxide. The poly (EBT) film-coated electrode exhibited excellent electrocatalytic activity towards the oxidation of rabeprazole sodium (RAB sodium) and domperidone (DOM) in Britton-Robinson buffer (pH 4.0). The polymer film modified electrode conspicuously enhanced the redox currents of the cited mixture and could sensitively and separately determine them. Both cyclic voltammetry (CV) and square wave adsorptive stripping voltammetric (SWAdSV) methods were utilized to determine this mixture. The linearity of CV ranged from 4.1120 mM and 5.2-90 mM for RAB sodium and DOM, respectively while SWAdSV was 7.5-80310(-7) M and 570310(-7) M for RAB sodium and DOM, respectively. With good selectivity and sensitivity, the present method provides a simple method for selective detection of RAB sodium and DOM binary mixture in synthetic mixtures and biological fluids.

• 出版日期2017-6