A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

作者：Browne Duncan L; Baumann Marcus; Harji Bashir H; Baxendale Ian R; Ley Steven V^*

来源：Organic Letters, 2011, 13(13): 3312-3315.

DOI：10.1021/ol2010006

A new machine for conducting continuous flow processes at low temperatures on a laboratory scale is reported. The use of this cryogenic flow reactor has been demonstrated by the preparation of a variety of (hetero)aromatic boronic acids and esters via lithium halogen exchange chemistry. Furthermore, scale-up of the reaction conditions not only demonstrates the application of this device for the preparation of useful building blocks but also combines the ability to process n-butyllithium directly through pump heads attached to the unit.

• 出版日期2011-7-1