Vitamin E protects against stress-induced gastric mucosal lesions in rats more effectively than vitamin C

作者：Ohta Yoshiji^*; Imai Yoichiro; Kaida Shingo; Kamiya Yoshio; Kawanishi Minoru; Hirata Ichiro

来源：Biofactors, 2010, 36(1): 60-69.

DOI：10.1002/biof.73

• gastric mucosal lesion
• water immersion restraint stress (rat)
• vitamin E
• vitamin C
• oxidative damage

In this study, we examined the protective effects of vitamin E (VE) against gastric mucosal lesions induced by water immersion restraint stress (WIRS) in rats in comparison with that of vitamin C (VC). The gastric mucosa of rats with 6 h of WIRS showed lesions with bleeding, decrease in nonprotein SH, VC, VE, and adherent mucus concentrations and constitutive nitric oxide synthase activity, and increase in lipid peroxide and NOx (nitrite/nitrate) concentrations and myeloperoxidase, xanthine oxidase, and inducible nitric oxide synthase activities. Either VE (0.05 or 0.5 mmol/kg) or VC (0.5 or 1.5 mmol/kg) was orally administered to rats with 6 h of WIRS just before the onset of the stress. Both doses of preadministered VE prevented gastric mucosal lesion development and attenuated all these changes in gastric mucosal components and enzymes studied, whereas only the higher dose of preadministered VC suppressed the changes in all parameters studied. These results indicate that orally administered VE protects against WIRS-induced gastric mucosal lesions in rats more effectively than orally administered VC. These results also suggest that the administered VE protects against gastric mucosal lesions in rats with WIRS through its antioxidant and anti-inflammatory actions in the gastric mucosa in the same way as the administered VC.

• 出版日期2010-2