A Unifying Model-Based Hypothesis for the Diverse Waveforms of Infantile Nystagmus Syndrome

作者：Wang Zhong I^*; Dell'Osso Louis F

来源：Journal of Eye Movement Research, 2011, 4(1): 1.

• Infantile Nystagmus Syndrome
• mechanism
• waveforms
• model
• simulation

We expanded the original behavioral Ocular Motor System (OMS) model for Infantile Nystagmus Syndrome (INS) by incorporating common types of jerk waveforms within a unifying mechanism. Alexander's law relationships were used to produce desired INS null positions and sharpness. At various gaze angles, these relationships influenced the IN slow-phase amplitudes differently, thereby mimicking the gaze-angle effects of INS patients. Transitions from pseudopendular with foveating saccades to jerk waveforms required replacing braking saccades with foveating fast phases and adding a resettable neural integrator in the pursuit pre-motor circuitry. The robust simulations of accurate OMS behavior in the presence of diverse INS waveforms demonstrate that they can all be generated by a loss of pursuit-system damping, supporting this hypothetical origin.

• 出版日期2011