A novel, concise and efficient protocol for non-natural piperidine compounds

作者:Chavan Subhash P*; Dumare Nilesh B; Pawar Kailash P
来源:RSC Advances, 2014, 4(62): 32594-32598.
DOI:10.1039/c4ra04558k

摘要

Formal synthesis of L-altro-1-deoxynojirimycin, cis-3-hydroxypipecolic acid along with synthesis of (R)-piperidinol and a conceptually different advanced intermediate for non-natural piperidine alkaloids is reported from cis-butene-1,4-diol. The key reactions involved are Johnson-Claisen rearrangement, Sharpless asymmetric dihydroxylation, reductive lactamization and novel regioselective elimination.

  • 出版日期2014