Neurophysiological findings in migraine - Do they reflect pathophysiological events or epiphenomena?

作者：Probst T^*; Wolters A; Benecke R; Kunesch E

来源：Klinische Neurophysiologie, 2004, 35(1): 22-38.

DOI：10.1055/s-2003-814844

• migraine
• pathophysiology
• cortex
• hyperexcitability
• evoked potentials

Neuronal dysfunctions of the cortex and brainstem play a major role in the pathophysiology of migraine. Functional brain imaging (fMRI), perfusion measurements and electrophysiological investigations such as EEG and MEG, multimodal evoked potentials, event-related potentials and reflex measurements have revealed many abnormal and even contradictory findings. These depend on the investigation time within the migraine cycle (interictual, aura and acute headache) and partly on the migraine subtype (migraine with or without aura). Dysfunctions of filter mechanisms protecting the brain from an overflow of sensory input might play a crucial role in inducing migraine attacks. Competing pathophysiological models suggest neuronal hyperexcitability within the CNS, but also hypoexcitability of the cerebral cortex as predisposing factors in migraine.

• 出版日期2004-3