Docetaxel-loaded SiO2@Au@GO core-shell nanoparticles for chemo-photothermal therapy of cancer cells

作者：Li, Xiaolin; Yang, Zhi; Hu, Nantao; Zhang, Liying; Zhang, Yafei^*; Yin, Lei^*

来源：RSC Advances, 2016, 6(54): 48379-48386.

DOI：10.1039/c6ra03886g

• SILICA-COATED GRAPHENE
• MULTIFUNCTIONAL NANOPARTICLES
• GOLD NANOPARTICLES
• DRUG-DELIVERY
• OXIDE
• RELEASE
• NANOCOMPOSITES
• ENHANCEMENT
• IRRADIATION
• DOXORUBICIN

The multifunctional antitumor SiO2@Au@GO core-shell nanoparticles (NPs) have been fabricated for serving as drug nanocarrier and photothermal inducer. The core-shell NPs exhibited high loading capacity of docetaxel (Dtxl) and pH-dependent drug release property as well as low cytotoxicity (concentration < 0.2 mg mL(-1)). Compared with chemotherapy alone, human prostate cancer cell incubated with Dtxl-loaded SiO2@Au@GO NPs in vitro were found to have undergone morbidity on exposure to near-infrared (NIR) light (780 nm, 5 W cm(-2)). It is expected that the multifunctional nanoparticles with unique core-shell structure will lead to new opportunities in nanomedicine.

• 出版日期2016
• 单位上海交通大学; 中国人民解放军第二军医大学; 天津市中医药研究院附属医院