Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

作者:Wang Lijun*; Min Yue; Xu Doudou; Yu Fengjiao; Zhou Wuzong; Cuschieri Alfred
来源:Chemical communications, 2014, 50(76): 11147-11150.
DOI:10.1039/c4cc03082f

摘要

We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.