Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts

作者：Veth Cornelis P M^*; Arns Martijn; Drinkenburg Wilhelmus; Talloen Willem; Peeters Pieter J; Gordon Evian; Buitelaar Jan K

来源：Psychiatry Research, 2014, 219(1): 221-224.

DOI：10.1016/j.psychres.2014.05.021

• Catechol-O-Methyltransferase Val158Met polymorphism
• Electroencephalographic alpha peak frequency
• Major depressive disorder

This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.

• 出版日期2014-9-30