Dose-function Histogram Evaluation Using Tc-99m-GSA SPECT/CT Images for Stereotactic Body Radiation Therapy Planning for Hepatocellular Carcinoma Patients: A Dosimetric Parameter Comparison

作者：Toya Ryo; Saito Tetsuo; Shiraishi Shinya; Kai Yudai; Murakami Ryuji; Matsuyama Tomohiko; Watakabe Takahiro; Sakamoto Fumi; Tsuda Noriko; Shimohigashi Yoshinobu; Yamashita Yasuyuki; Oya Natsuo

来源：Anticancer Research, 2018, 38(3): 1511-1516.

DOI：10.21873/anticanres.12378

• Hepatocellular carcinoma
• stereotactic body radiation therapy
• dose-function histogram
• dose-volume histogram
• radiation-induced liver disease

Background/Aim: We evaluated the influence of previous treatments on the parametric discrepancies between dose-volume histograms (DVHs) and dose-function histograms (DFHs) generated based on Tc-99m-GSA SPECT images of hepatocellular carcinoma (HCC) patients treated with stereotactic body radiation therapy (SBRT). Patients and Methods: Twelve patients underwent SBRT at 30-40 Gy. Registration between planning CT and SPECT/CT images was performed, and DFH parameters were calculated as follows: Fx=(sum of the counts within the liver volume receiving a dose of more than x Gy/sum of the counts within the whole liver volume) x100. The discrepancy between Fx and Vx (Dx) was also calculated. Results: The number of previous treatments for lesions other than SBRT-treated lesions (>= 2 vs. < 2) exhibited a significant influence on the absolute values of D-10, D-15, and D-20 (p<0.05). Conclusion: Previous treatment significantly influences the parametric discrepancy between DFH and DVH.

• 出版日期2018-3