A novel nucleic acid aptamer tag: a rapid fluorescence strategy using a self-constructing G-quadruplex from AGG trinucleotide repeats

作者:Fu, Boshi; Park, Yoojin; Kim, Ki Tae; Chen, Kun; Zou, Guangrong; Wei, Qi; Peng, Shuang; Chen, Yuqi; Kim, Byeang Hyean*; Zhou, Xiang*
来源:Chemical communications, 2018, 54(81): 11487-11490.
DOI:10.1039/c8cc05197f

摘要

Herein, we have developed a novel fluorescence labeling strategy for nucleic acid aptamers based on self-assembling between AGG tri-nucleotide repeats and a pyrene-modified oligonucleotide. This strategy could be an effective tool for developing targeting-imaging systems and biosensor systems to detect target molecules.