A comparison of the effect of glitazones on serum sialic acid in patients with type 2 diabetes

作者：Rahman Inayat Ur^*; Idrees Muhammad; Salman Mohammad; Khan Rooh Ullah; Khan M I; Amin Fazli; Jan Naeem Ullah

来源：Diabetes and Vascular Disease Research, 2012, 9(3): 238-240.

DOI：10.1177/1479164111428629

• Pioglitazone
• rosiglitazone
• serum sialic acid
• type 2 diabetes

Although management of hyperglycaemia represents one of the principal treatment goals of diabetes therapy, the high incidence of cardiovascular (CV) complications in diabetes also needs effective management. Therefore, the present study was designed to determine and compare the effect of glitazones on serum sialic acid (SSA), a known risk marker for CV disease, along with fasting plasma glucose (FPG), glycohaemoglobin (HbAl-c) and blood lipids, in overweight, previously only diet-treated patients with type 2 diabetes (n=60). The study was conducted for a period of 12 months. Significant improvement in FPG and HbAl-c were shown by both rosiglitazone (p<0.003 and p<0.001, respectively) and pioglitazone (p<0.005 and p<0.001, respectively), compared with baseline, and pioglitazone showed greater beneficial effects on other parameters monitored, significantly reducing total cholesterol (TC) (p <= 0.05). Both the drugs showed a decrease in SSA and no significant differences were observed between the groups. However, the decrease was significant only in the pioglitazone-treated group at month 12 (p <= 0.05), compared with baseline. A significant decrease in SSA by pioglitazone indicates its greater cardioprotective effect compared with rosiglitazone.

• 出版日期2012-7