Facile Regiocontrolled Three-Step Synthesis of Poly-Substituted Furans, Pyrroles, and Thiophenes: Consecutive Michael Addition of Methyl Cyanoacetate to alpha,beta-Enone, CuI-Mediated Aerobic Oxidation, and Acid-Catalyzed Paal-Knorr Synthesis

作者：Kim Se Hee; Lim Jin Woo; Lim Cheol Hee; Kim Jae Nyoung^*

来源：BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 33(2): 620-624.

DOI：10.5012/bkcs.2012.33.2.620

• Furans
• Pyrroles
• Thiophenes
• CuI
• Paal-Knorr synthesis

An efficient synthesis of poly-substituted furans, pyrroles, and thiophenes was carried out in a regiocontrolled manner via a three-step process; (i) conjugate addition of methyl cyanoacetate derivatives to alpha,beta-enones, (ii) CuI-mediated aerobic oxidation, and (iii) Paal-Knorr type synthesis of five-membered heterocycles.

• 出版日期2012-2-20