Diffusing-wave spectroscopy from head-like tissue phantoms: influence of a non-scattering layer

作者：Jaillon Franck^*; Skipetrov Sergey E; Li Jun; Dietsche Gregor; Maret Georg; Gisler Thomas

来源：Optics Express, 2006, 14(22): 10181-10194.

DOI：10.1364/OE.14.010181

We investigate the influence of a non-scattering layer on the temporal field autocorrelation function of multiple scattered light g((1))(r, t) from a multilayer turbid medium such as the human head. Data from Monte Carlo simulations show very good agreement with the predictions of the correlation-diffusion equation with boundary conditions taking into account non-diffusive light transport within the non-scattering layer. Field autocorrelation functions measured at the surface of a multilayer phantom including a non-scattering layer agree well with theory and simulations when the source-receiver distance is significantly larger than the depth and the thickness of the non-scattering layer. Our results show that for source-receiver distances large enough to probe the dynamics in the human cortex, the cortical diffusion coefficient obtained by analyzing field autocorrelation functions neglecting the presence of the non-scattering cerebrospinal fluid layer is underestimated by about 40% in situations representative of the human head.

• 出版日期2006-10-30