An unexpected multi-component reaction to synthesis of 3-(5-amino-3-methyl-1H-pyrazol-4-yl)-3-arylpropanoic acids in ionic liquid

作者：Xiao Zhiyong; Lei Min^*; Hu Lihong

来源：Tetrahedron Letters, 2011, 52(52): 7099-7102.

DOI：10.1016/j.tetlet.2011.10.099

• Green chemistry
• Multi-component reaction
• [bmim]BF4
• Aldehyde
• Meldrum's acid

A new, one-pot, four-component condensation of 3-methyl-1H-pyrazol-5(4H)-one, ammonium acetate, aromatic aldehydes, and meldrum's acid in [bmim]BF4 as solvent is described for the synthesis of 3-(5-amino-3-methyl-1H-pyrazol-4-yl)-3-arylpropanoic acid derivatives. This methodology resulting in excellent isolated yields in short reaction time is characterized by simple work up procedure and little environmental impact.

• 出版日期2011-12-28
• 单位中国科学院上海药物研究所