Modification of chitosan with monomethyl fumaric acid in an ionic liquid solution

作者：Wang Zhaodong; Zheng Liuchun^*; Li Chuncheng; Zhang Dong; Xiao Yaonan; Guan Guohu; Zhu Wenxiang

来源：Carbohydrate Polymers, 2015, 117: 973-979.

DOI：10.1016/j.carbpol.2014.10.021

• Ionic liquid
• Chitosan
• Monomethyl fumaric acid

Antibacterial and antioxidant monomethyl fumaric acid (MFA) was selected to modify chitosan, using aqueous solution of an ionic liquid as a homogeneous and green reaction media. The chemical structures of resulting polymers were systematically characterized by H-1 NMR, diffusion ordered spectroscopy, solid C-13 NMR and wide-angle X-ray diffraction. The results show that two kinds of MFA modified chitosan materials with totally different chemical structures have been synthesized. One product was a MF-chitosan salt composed of chitosan cation and MFA anion, which was obtained with the mediation of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide. The other one synthesized with the mediation of EDC was a MF-chitosan amide in which MFA and chitosan are covalently attached. Solubility of chitosan has been improved, and MF-chitosan salt can be readily dissolved in water. The antioxidant activity has been enhanced with the introduction of MFA, irrespective of the chemical structure.

• 出版日期2015-3-6
• 单位中国科学院大学; 中国科学院化学研究所