A disynaptic feedback network activated by experience promotes the integration of new granule cells

作者：Alvarez Diego D; Giacomini Damiana; Min Yang Sung; Trinchero Mariela F; Temprana Silvio G; Buttner Karina A; Beltramone Natalia; Schinder Alejandro F

来源：Science, 2016, 354(6311): 459-465.

DOI：10.1126/science.aaf2156

<jats:title>Integration of adult-born brain cells</jats:title>
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Physical exercise or exploration of a novel environment greatly influences the production, maturation, and connectivity of adult-born neurons. Alvarez
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investigated how experience affects the incorporation of adult-born neurons into the hippocampal network. A brief period of sensory enrichment when new neurons were 9 to 10 days old led to neurons having larger dendrites and more functional spine synapses. A disynaptic preexisting feedback circuit promoted the growth and integration of the new cells.
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<jats:italic>Science</jats:italic>
, this issue p.
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• 出版日期2016-10-28