Body mass index, diabetes and survival after diagnosis of endometrial cancer: A report from the HUNT-Survey

作者：Lindemann Kristina^*; Cvancarova Milada; Eskild Anne

来源：Gynecologic Oncology, 2015, 139(3): 476-480.

DOI：10.1016/j.ygyno.2015.09.088

• Endometrial cancer
• Diabetes
• BMI
• Survival
• Epidemiology

Objective. We studied the association of body mass index (BMI) and diabetes with all-cause death and endometrial cancer-specific death among women with endometrial cancer (EC).
Methods. Included were 337 women in the Health Surveys in North-Trondelag, Norway who were followed from EC diagnosis to death or end of follow-up, 30th June 2012. Risks of death associated with BMI and diabetes were estimated as hazard ratios (HRs) with 95% confidence intervals (95% CI). The risks of EC-specific death were estimated as sub-HRs, after adjustment for competing causes of death. We also studied the risk of death associated with diabetes in women with BMI <25 kg/m(2) and in women with BMI 25 kg/m(2).
Results. During the median follow-up time of 6.7 years, 166 women (493%) died. Diabetes increased the risk of all-cause death (HR 2.14,95% CI: 1.26-3.63) and endometrial cancer-specific death (SHR, 2.62,95% CI: 1.07-6.43) after adjustment for age, histological type and stage of EC. BMI was not associated with risk of all-cause or EC-specific death. The increased risk of both all-cause death and EC specific death in diabetic women seemed to be more pronounced in women with BMI < 25 kg/m(2) (HR 6.35,95% CI: 1.90-21.14) compared to women with BMI >25 kg/m(2) (HR 1.80, 95% CI: 0.98-333).
Conclusions. Diabetes, but not BMI, was associated with increased risk of all-cause death and death from EC. The increased risk of death associated with diabetes seemed to be most pronounced in women with BMI <25 kg/m(2).

• 出版日期2015-12