Meta-analysis of programmed cell death 1 polymorphisms with systemic lupus erythematosus risk

作者：Gao, Jie^*; Gai, Nan; Wang, Li; Liu, Kang; Liu, Xing-Han; Wei, Lin-Ting; Tian, Tian; Li, Shan-Li; Zheng, Yi; Deng, Yu-Jiao; Dai, Zhi-Jun; Fu, Rong-Guo^*

来源：Oncotarget, 2017, 8(22): 36885-36897.

DOI：10.18632/oncotarget.16378

• PDCD1
• SLE
• polymorphism
• risk
• meta-analysis

The association of polymorphisms in programmed cell death 1 (PDCD1) gene with systemic lupus erythematosus (SLE) risk is inconsistent across different studies. This meta-analysis is aimed to provide reliable evidence to the association of five common PDCD1 polymorphisms (PD1.1, PD1.2, PD1.3, PD1.5 and PD1.6) with SLE risk. A total of 28 studies with 4,344 SLE cases and 5,474 healthy controls were included in this meta-analysis. PD1.3 polymorphism was significantly associated with SLE in the overall population (A vs. G: OR = 1.35, 95% CI = 1.12-1.63; GA vs. GG: OR = 1.41, 95% CI = 1.12-1.76; AA+GA vs. GG: OR = 1.41, 95% CI = 1.13-1.7). In the stratified analyses based on ethnicity, we found a significant association in Caucasians and in Mexicans. In the subgroup analyses by gender, a significant association was found between PD1.3 polymorphism and SLE risk in males. The results also suggested an association between the PD1.6 polymorphism and decreased SLE risk (A vs. G: OR = 0.84, 95% CI = 0.73-0.96). Our meta-analysis revealed that PD1.3 polymorphism may increase the susceptibility to SLE, particularly in Caucasians, while PD1.6 may be a protective factor to SLE.

• 出版日期2017-5-30
• 单位西安交通大学