Antiretroviral therapy abrogates association between arginase activity and HIV disease severity

作者：Cloke T E; Abebe T; Hailu A; Munder M; Taylor G P; Mueller I; Kropf P^*

来源：Transactions of the Royal Society of Tropical Medicine and Hygiene, 2010, 104(11): 746-748.

DOI：10.1016/j.trstmh.2010.08.004

• HIV
• Immune response
• T cells
• CD4 cell count
• Arginase
• L-arginine

Arginase-induced L-arginine deprivation is emerging as a key mechanism for the downregulation of immune responses. We hypothesised that arginase activity increases with disease severity in HIV-seropositive patients. Our results show that peripheral blood mononuclear cells (PBMCs) from 23 HIV-seropositive patients with low CD4(+) T cell counts (<= 350 cells/mu l) expressed significantly more arginase compared with 21 patients with high CD4(+) T cell counts. Furthermore, we found a significant association between the two principal prognostic markers used to monitor HIV disease (CD4(+) T cell count and plasma viral load) and PBMC arginase activity in antiretroviral therapy naive patients but not in patients undergoing therapy.

• 出版日期2010-11