Secondary Epstein-Barr virus-associated angioimmunoblastic T-cell lymphoma in a patient with diffuse large B-cell lymphoma: report of a case and review of literature

作者：Yang, Yonggong; Xu, Peipei; Wang, Fan; Fan, Xiangshan; Ouyang, Jian; Chen, Bing^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(2): 1877-1881.

• Angioimmunoblastic T-cell lymphoma
• Epstein-Barr virus
• diffuse large B-cell lymphoma
• case report

We report a case of secondary Epstein-Barr virus-associated angioimmunoblastic T-cell lymphoma (AITL) developed after the initial diagnosis of diffuse large B-cell lymphoma (DLBCL). A 59-year-old Chinese male patient was diagnosed as DLBCL based on typical histological and immunohistochemical characteristics in biopsy of the enlarged cervical lymph nodes. The patient received 8 cycles of chemotherapy with R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and achieved complete remission. Nine months after initial diagnosis of DLBCL, the patient was hospitalized again because of pain in the neck and some enlarged cervical lymph nodes. The lymph node biopsy was performed, but this time the tumor was composed of small to medium-sized lymphoid cells with CD3, CD4, CD10, PD-1 and CXCL13 positive on immunohistochemical staining. The tumor cells were strong positive for EBER by in situ hybridization. The findings of lymph node biopsy were compatible with EBV-associated AITL. DICE chemotherapy (dexamethasone, ifosfamide, cisplatin and etoposide) was then administered, resulting in none response of the disease with pancytopenia and suppression of cellular immunity. To our knowledge, this is the first case of EBV-associated AITL originated from DLBCL. We suggest the patients with lymphoma should perform lymph node biopsy regularly in the course of the disease progression to detect of a secondary lymphoma.

• 出版日期2017
• 单位南京大学