Associations of dairy intake with glycemia and insulinemia, independent of obesity, in Brazilian adults: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

作者：Drehmer Michele^*; Pereira Mark A; Schmidt Maria Ines; Molina Maria Del Carmen B; Alvim Sheila; Lotufo Paulo A; Duncan Bruce B

来源：American Journal of Clinical Nutrition, 2015, 101(4): 775-782.

DOI：10.3945/ajcn.114.102152

• cohort studies
• dairy products
• glycemia
• insulinemia
• obesity

Background: Inverse associations between dairy intake and the risk of type 2 diabetes have been shown, but more studies are needed, especially from low- and middle-income countries.
Objective: The objective was to describe the association between dairy products and direct measures of glycemic status in adults without known diabetes.
Design: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) includes 15,105 adults, aged 35-74 y, enrolled from universities and research institutions in 6 Brazilian capital cities. We excluded participants with a known diabetes diagnosis, cardiovascular diseases, and cancer. Dairy consumption was assessed by a food-frequency questionnaire, and we computed servings per day for total and subgroups of dairy. Associations with fasting blood glucose (FG) and fasting insulin, 2-h postload glucose (PG), 2-h postload insulin (PI), glycated hemoglobin (Hb A(1c)), and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed through multivariable linear regression analysis with adjustment for demographic characteristics, behavioral risk factors, other dietary factors, and anthropometric measurements.
Results: The sample size after exclusions was 10,010. The intake of total dairy was inversely associated with FG (linear 0 for dairy servings/d = -0.46 +/- 0.2 mg/dL), PG (-1.25 +/- 0.5 mg/dL), PI (-1.52 +/- 0.6 mg/dL), Hb A(1c) (-0.02 +/- 0.0%), and HOMA-IR (-0.04 +/- 0.0) after adjustment for all covariates (P < 0.05 for all). The findings were consistent across categories of sex, race, obesity status, and dairy fat amount (reduced-fat vs. full-fat dairy). Fermented dairy products showed particularly strong inverse associations with the outcomes, with adjusted differences for a 1-serving/d increment of 0.24 (95% CI: -0.46, -0.02) mg/dL for FG, -0.86 (-1.42, -0.30) mg/dL for PG, and -0.01% (-0.02%, 0.00%) for Hb Ale. Myristic acid was the only nutrient that appeared to mediate the association between dairy intake and glycemia.
Conclusion: Dairy intake, especially fermented dairy, was inversely associated with measures of glycernia and insulinemia in Brazilian adults without diagnosed diabetes.

• 出版日期2015-4