A New Quinolone and Other Constituents from the Fruits of Tetradium ruticarpum: Effects on Neutrophil Pro-Inflammatory Responses

作者：Wang Tzu Ying; Wu Jin Bin^*; Hwang Tsong Long; Kuo Yueh Hsiung; Chen Jih Jung

来源：Chemistry and Biodiversity, 2010, 7(7): 1828-1834.

DOI：10.1002/cbdv.200900289

The fruit of Tetradium ruticarpum is widely used in healthcare products for the improvement of blood circulation, headache, abdominal pain, amenorrhea, chill limbs, migraine, and nausea. A new quinolone, 2-[(6Z,9Z)-pentadeca-6,9-dienyl]quinolin-4(1H)-one (1), has been isolated from the fruits of T ruticarpum, together with eleven known compounds. The structure of the new compound was determined by NMR and MS analyses. Rutaecarpine (4), evodiamine (5), and skimmianine (7) exhibited inhibition (IC(50 <=)20.9 mu M) of O(2)(center dot-) generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). In addition, 1, evocarpine (2), 4, 7, and evodol (8) inhibited fMLP/CB-induced elastase release with IC(50) values <= 14.4 mu M.

• 出版日期2010
• 单位中国医科大学; 长春大学