Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer

作者：De Cobelli Ottavio; Buonerba Carlo; Terracciano Daniela; Bottero Danilo; Lucarelli Giuseppe; Bove Pierluigi; Altieri Vincenzo; Coman Ioman; Perdona Sisto; Facchini Gaetano; Berretta Massimiliano; Di Lorenzo Giuseppe; Grieco Paolo; Novellino Ettore; Franco Renato; Caraglia Michele; Manini Claudia; Mirone Vincenzo; De Placido Sabino; Sonpavde Guru; Ferro Matteo^*

来源：Future Oncology, 2015, 11(22): 3091-3098.

DOI：10.2217/fon.15.249

• Gleason score
• prostate cancer
• urotensin II receptor

Aim: A higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients. Methods: A retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry. Results: A total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55-68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23-100.48). Conclusions: UTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.

• 出版日期2015