科研之友
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摘要
Mitochondria are dynamic organelles which adapt their morphology by fusion and fission events to the bio-energetic requirements of the cell. Cardiac and skeletal muscles are tissues with high energy demand and mitochondrial plasticity plays a key role in the homeostasis of these cells. Indeed, alterations in mitochondrial morphology, distribution and function are common features in catabolic conditions. Moreover, dysregulation of mitochondrial dynamics affects the signaling pathways that regulate muscle mass. This review discusses the recent findings of the role of mitochondrial fusion/fission and mitophagy in the control of proteolytic pathways. This article is part of a special issue entitled %26quot;Focus on Cardiac Metabolism%26quot;.
- 出版日期2013-2
