科研之友
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摘要
In this work, from the point of calcium ions in the cytosol, we extend a V(m)-[Ca(2 )](cyt) model to explain the changes of action potential V(m) of the plasma membrane and the calcium concentration in the cytosol [Ca(2 )](cyt) under an alternating electric field in cells. An alternating external electric field may exert an oscillating force to each of the free electrolytes, existing on both sides of the plasma membrane. The mechanism for the alternating electric field induced-effects on V(m) and [Ca(2 )](cyt) is elucidated. The simulation results show a correlation between the changes of [Ca(2 )](cyt) and the alternating electric field. When the numerical ratio between the intensity E(0)(mV/m) and the frequency nu (Hz) of the field was about 1-2, the [Ca(2 )](cyt) signal is changed dramatically. The bioactive changes of [Ca(2 )](cyt) appear at low frequency, in the range of 0-100 Hz.
- 出版日期2009-1
- 单位南开大学
