Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population

作者：Kyogoku Chieko^*; Yanagi Masaya; Nishimura Kunihiro; Sugiyama Daisuke; Morinobu Akio; Fukutake Masaaki; Maeda Kiyoshi; Shirakawa Osamu; Kuno Takayoshi; Kumagai Shunichi

来源：Psychiatry Research, 2011, 185(1-2): 16-19.

DOI：10.1016/j.psychres.2009.11.003

• Schizophrenia
• Calcineurin A gamma subunit (PPP3CC)
• Early growth response 3 (EGR3)

To examine the association of PPP3CC (rs10108011 and rs2461491) and EGR3 (rs3750192) single-nucleotide polymorphisms (SNPs) with Japanese schizophrenia, we performed a case-control association study using 337 patients and 369 healthy controls. As a result, by our moderated cohort-size study, PPP3CC and EGR3 are not genetic risk factors for schizophrenia, whereas meta-analysis showed weak association of rs10108011 with schizophrenia in the Japanese population (odds ratio (OR) = 1.12, P = 0.01).

• 出版日期2011-1-30