A mild and convenient one-pot two-step synthesis of hydroxyiminodihydrobenzofurans mediated by silica gel under microwave activation conditions

作者：Barange Deepak Kumar; Raju B Rama; Kavala Veerababurao; Kuo Chun Wei; Tu Yu Chen; Yao Ching Fa^*

来源：Tetrahedron, 2010, 66(21): 3754-3760.

DOI：10.1016/j.tet.2010.03.051

A convenient one-pot two-step procedure for the synthesis of hydroxyiminodihydrobenzofurans assisted by microwave irradiation in presence of silica gel is described herein. Cyclic 1,3-dicarbonyl compounds reacted smoothly with various nitroolefins to furnish hydroxyiminodihydrobenzofuran derivatives as the mixture of E and Z isomers. Clean reaction conditions, no work-up procedure, easy isolation and good yields of the products are the salient features of the methodology.

• 出版日期2010-5-22