科研之友
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摘要
Asymmetric synthesis of novel (1H-benzo[d]imidazol-2-ylthio)- and (di-n-butylamino)acetamides is described. The o-nitrobenzyl oxime ethers were reduced with borane in the presence of oxazaborolidenes derived from norephedrine or diphenylvalinol and diphenylphosphinic amide was reduced with modified sodium tetrahydroborate catalyzed with beta-ketoiminato cobalt(II) complex to the corresponding amines with high yields and moderate enantiomeric excess. Reaction of amines with 2-chloroacetyl chloride and next with thiobenzimidazole or n-dibutylamine gave corresponding products with high yields.
- 出版日期2013-4
