Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice

作者：Almeida da Luz Sonia Cristina; Daubermann Melissa Falster; Thome Gustavo Roberto; dos Santos Matheus Muelling; Ramos Angelica; Salazar Gerson Torres; Teixeira da Rocha Joao Batista; Barbosa Nilda Vargas^*

来源：Analytical Cellular Pathology, 2015, 2015: 1-10.

DOI：10.1155/2015/784612

Tellurium compounds may be cytotoxic to different cells types. Thus, this work evaluated the effect of diphenyl ditelluride ((PhTe)2), an organotellurium commonly used in organic synthesis, on the morphology of liver, kidney, and lung. Adult mice were acutely (a subcutaneous single dose: 250 mu mol/kg) or subchronically (one daily subcutaneous dose: 10 or 50 mu mol/kg for 7 and 14 days) exposed to (PhTe)(2). Afterwards, the histological analyses of liver, kidney, and lungs were performed. Liver histology revealed that the hepatocytes of mice subchronically exposed to (PhTe)(2) presented cytoplasmic vacuolization, hydropic degeneration, and hyperchromatic nuclei. Subchronic exposure to 50 mol/kg (PhTe)(2) also caused hepatic necrosis. Microvesicular and macrovesicular steatosis were identified in liver of mice acutely exposed to (PhTe)(2). Acute and subchronic intoxication with (PhTe)(2) induced changes on epithelial cells of renal tubules, namely, loss of brush border and cytoplasmatic vacuolization. Atrophy and hypertrophy, cast proteinaceous formation, and acute tubular necrosis were also identified in renal tissue. Mice subchronically exposed to 50 mu mol/kg (PhTe)(2) developed intra-alveolar edema and alveolar wall congestion in some areas of lungs. Acute exposure to (PhTe)(2) did not cause histological changes in lungs. Our data show that (PhTe)(2) may be considered a histotoxic agent for liver, kidney, and lung.

• 出版日期2015