Air pollution is associated with brainstem auditory nuclei pathology and delayed brainstem auditory evoked potentials

作者：Calderon Garciduenas Lilian^*; D'Angiulli Amedeo; Kulesza Randy J; Torres Jardon Ricardo; Osnaya Norma; Romero Lina; Keefe Sheyla; Herritt Lou; Brooks Diane M; Avila Ramirez Jose; Delgado Chavez Ricardo; Medina Cortina Humberto; Oscar Gonzalez Gonzalez Luis

来源：International Journal of Developmental Neuroscience, 2011, 29(4): 365-375.

DOI：10.1016/j.ijdevneu.2011.03.007

• Air pollution
• Alpha synuclein
• Auditory nuclei
• Brainstem inflammation
• Brainstem evoked auditory potentials
• Beta amyloid
• Children
• Neuroinflammation

We assessed brainstem inflammation in children exposed to air pollutants by comparing brainstem auditory evoked potentials (BAEPs) and blood inflammatory markers in children age 96.3 +/- 8.5 months from highly polluted (n = 34) versus a low polluted city (n = 17). The brainstems of nine children with accidental deaths were also examined. Children from the highly polluted environment had significant delays in wave III (t(50) = 17.038; p <0.0001) and wave V (t(50) = 19.730; p <0.0001) but no delay in wave I (p = 0.548). They also had significantly longer latencies than controls for interwave intervals 1 Ill, III V, and I V (all t(50)>7.501; p <0.0001), consisting with delayed central conduction time of brainstem neural transmission. Highly exposed children showed significant evidence of inflammatory markers and their auditory and vestibular nuclei accumulated alpha synuclein and/or beta amyloid(1-42). Medial superior olive neurons, critically involved in BAEPs, displayed significant pathology. Children's exposure to urban air pollution increases their risk for auditory and vestibular impairment.

• 出版日期2011-6