Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model

作者：Lin Yu-Wei; Zhou Qi Tony; Han Mei-Ling; Chen Ke; Onufrak Nikolas J.; Wang Jiping; Turnidge John D.; Howden Benjamin P.; Forrest Alan; Chan Hak-Kim^*; Li Jian^*

来源：Antimicrobial Agents and Chemotherapy, 2018, 62(2): e01790-17.

DOI：10.1128/AAC.01790-17

• polymyxin
• respiratory tract infections
• pulmonary administration
• Acinetobacter baumannii
• Klebsiella pneumoniae
• Gram-negative bacteria

The pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. The area under the concentration-time curve over 24 h in the steady state divided by the MIC (AUC/MIC) in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin.

• 出版日期2018-2