A continuous heparin infusion does not prevent catheter-related thrombosis in infants after cardiac surgery

作者：Schroeder Alan R^*; Axelrod David M; Silverman Norman H; Rubesova Erika; Merkel Elisabeth; Roth Stephen J

来源：Pediatric Critical Care Medicine, 2010, 11(4): 489-495.

DOI：10.1097/PCC.0b013e3181ce6e29

• catheters
• heparin
• pediatrics
• thrombosis
• echocardiography
• congenital heart defect
• thoracic surgery

Objective: To determine whether a continuous infusion of heparin reduces the rate of catheter-related thrombosis in neonates and infants post cardiac surgery. Central venous and intra-cardiac catheters are used routinely in postoperative pediatric cardiac patients. Catheter-related thrombosis occurs in 8% to 45% of pediatric patients with central venous catheters.
Design: Single-center, randomized, placebo-controlled, double-blinded trial.
Setting: Cardiovascular intensive care unit, university-affiliated children's hospital.
Patients: Children <1 yr of age recovering from cardiac surgery.
Interventions: Patients were randomized to receive either continuous heparin at 10 units/kg/hr or placebo. The primary end point was catheter-related thrombosis as assessed by serial ultrasonography.
Results: Study enrollment was discontinue

• 出版日期2010-7