Nanovectorization of DNA Through Cells Using Protamine Complexation

作者：Boukari Khaoula; Caoduro Cecile; Kacem Raoudha; Skandrani Nadia; Borg Christophe; Boulahdour Hatem; Gharbi Tijani; Delage Mourroux Regis; Hervouet Eric; Pudlo Marc; Picaud Fabien^*

来源：Journal of Membrane Biology, 2016, 249(4): 493-501.

DOI：10.1007/s00232-016-9890-5

• Nanovectorization
• Protamine
• Simulation

Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex.

• 出版日期2016-8