Discovery and Protein Engineering of Biocatalysts for Organic Synthesis

作者:Behrens Geoffrey A; Hummel Anke; Padhi Santosh K; Schaetzle Sebastian; Bornscheuer Uwe T*
来源:Advanced Synthesis & Catalysis, 2011, 353(13): 2191-2215.
DOI:10.1002/adsc.201100446

摘要

Modern tools for enzyme discovery and protein engineering substantially broadened the number of enzymes applicable for biocatalysis and helped to alter their properties such as substrate range, enantioselectivity, and stability under process conditions. In addition, these methods also enabled one to explore reactions for organic synthesis for which no suitable enzymes were available until recently. This review provides a summary of the different concepts and technologies, which are exemplified for various enzymes.

  • 出版日期2011-9