Molecules to modeling: Toxoplasma gondii oocysts at the human-animal-environment interface

作者：VanWormer Elizabeth^*; Fritz Heather; Shapiro Karen; Mazet Jonna A K; Conrad Patricia A

来源：Comparative Immunology, Microbiology and Infectious Diseases, 2013, 36(3): 217-231.

DOI：10.1016/j.cimid.2012.10.006

• Toxoplasma gondii
• One Health
• Oocyst
• Modeling
• Transport
• Molecular characterization
• Climate change
• Land use change
• Zoonotic disease
• Environmental resistance

Environmental transmission of extremely resistant Toxoplasma gondii oocysts has resulted in infection of diverse species around the world, leading to severe disease and deaths in human and animal populations. This review explores T. gondii oocyst shedding, survival, and transmission, emphasizing the importance of linking laboratory and landscape from molecular characterization of oocysts to watershed-level models of oocyst loading and transport in terrestrial and aquatic systems. Building on discipline-specific studies, a One Health approach incorporating tools and perspectives from diverse fields and stakeholders has contributed to an advanced understanding of T. gondii and is addressing transmission at the rapidly changing human animal environment interface.

• 出版日期2013-5