Protection against enamel demineralisation using toothpastes containing o-cymen-5-ol, zinc chloride and sodium fluoride

作者：Churchley David^*; Newby Craig S; Willson Richard; Haider Amir; Schemehorn Bruce; Lynch Richard J M

来源：International Dental Journal, 2011, 61: 55-59.

DOI：10.1111/j.1875-595X.2011.00050.x

• Demineralisation
• Zinc

To evaluate the ability of two experimental toothpastes containing 0.1% w/w o-cymen-5-ol, 0.6% w/w ZnCl2 and 0.320% w/w NaF to reduce demineralisation of sound human enamel compared with control toothpastes. Methods: Study 1: Specimens were treated with toothpaste slurries, followed by alternating periods in demineralising and neutral solutions. Demineralisation was assessed using surface microhardness (SMH). Study 2: Specimens were subjected to a 14 day cycling regime of alternating demineralisation / remineralisation with two toothpaste treatments per day, before and after demineralisation. Demineralisation was assessed by cross-sectional microhardness and mineral loss (Delta Z) was calculated. Test toothpastes were a) 0% w/w or 0.002% w/w NaF placebo, b) 0.055% w/w or 0.149% w/w NaF (dose response), c) 0.320% w/w NaF marketed product, d & e) 0.1% w/w o-cymen-5-ol, 0.6% w/w ZnCl2 and 0.320% w/w NaF (experimental toothpastes). Results: Study 1: Mean +/- SE % of baseline hardness values were a) 48.0 +/- 2.1(a), b) 66.7 +/- 1.7(b), c) 82.9 +/- 1.9(c), d) 91.7 +/- 1.4(d) and e) 94.6 +/- 2.1(d). Study 2: Mean +/- SE Delta Z values were a) 2114 +/- 187(a), b) 1206 +/- 132(b), c) 303 +/- 89(c), d) 19 +/- 73(c), and e)) 10 +/- 55(c). Letters represent different statistical groupings (P < 0.05). Conclusion: In study 1, both experimental toothpastes were statistically superior to the marketed product and in study 2; they were at least as effective as the marketed product at reducing caries lesion development.

• 出版日期2011-8