An N-terminal pro-atrial natriuretic peptide (NT-proANP) 'aggregation-prone' segment involved in isolated atrial amyloidosis

作者：Louros Nikolaos N; Iconomidou Vassiliki A; Tsiolaki Paraskevi L; Chrysina Evangelia D; Baltatzis Georgios E; Patsouris Efstratios S; Hamodrakas Stavros J^*

来源：FEBS LETTERS, 2014, 588(1): 52-57.

DOI：10.1016/j.febslet.2013.10.049

• Natriuretic peptide
• N-terminal pro-atrial natriuretic peptide (NT-proANP)
• Amyloid fibril
• Isolated atrial amyloidosis (IAA)
• Cardiac amyloidose

Isolated atrial amyloidosis (IAA) is a common localized form of amyloid deposition within the atria of the aging heart. The main constituents of amyloid fibrils are atrial natriuretic peptide (ANP) and the N-terminal part of its precursor form (NT-proANP). An 'aggregation-prone' heptapeptide ((114)KLRALLT(120)) was located within the NT-proANP sequence. This peptide self-assembles into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, ATR FT-IR spectroscopy and Congo red staining studies reveal. Consequently, remedies/drugs designed to inhibit the aggregation tendency of this 'aggregation-prone' segment of NT-proANP may assist in prevention/treatment of IAA, congestive heart failure (CHF) or atrial fibrillation (AF).

• 出版日期2014-1-3