A gene-based review of RGS4 as a putative risk gene for psychiatric illness

作者：Schwarz Emanuel

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2018, 177(2): 267-273.

DOI：10.1002/ajmg.b.32547

<jats:sec><jats:label /><jats:p>Considerable efforts have been made to characterize <jats:italic>RGS4</jats:italic> as a potential candidate gene for schizophrenia. Investigations span across numerous modalities and include explorations of genetic risk associations, mRNA and protein levels in the brain, and functionally relevant interactions with other candidate genes as well as links to schizophrenia relevant neural phenotypes. While these lines of investigations have yielded partially inconsistent findings, they provide a perspective on <jats:italic>RGS4</jats:italic> as an important part of a larger biological system contributing to schizophrenia risk. This gene‐based review aims to provide a comprehensive overview of published data from different experimental modalities and discusses the current knowledge of <jats:italic>RGS4</jats:italic>'s systems‐biological impact on the schizophrenia pathology.</jats:p></jats:sec>

• 出版日期2018-3