A cyanine-based colorimetric and fluorescence probe for detection of hydrogen sulfide in vivo

作者：Wang, Huan; Yang, Dan; Tan, Rui; Zhou, Zhang Jian; Xu, Rui; Zhang, Jun Feng^*; Zhou, Ying^*

来源：Sensors and Actuators B: Chemical , 2017, 247: 883-888.

DOI：10.1016/j.snb.2017.03.030

• Hydrogen sulfide
• Fluorescence
• Colorimetric
• Sensor
• In vivo imaging

This paper describes a cyanine-based colorimetric and fluorescence probe for the sensitive and selective detection of hydrogen sulfide (H2S). The mechanism of H2S detection is based on the reaction of hydro sulfide anion with a disulfide bond. The resulting product of the reaction of the probe with hydrogen sulfide can be detected in a colorimetric assay as it changes a color of the reaction mixture from green to pink in aqueous solutions. Simultaneously, a 25-fold increase in the fluorescence signal of the probe upon its interaction with hydrogen sulfide gives a unique opportunity for the usage of this probe for in vivo detection of H2S. In addition, the present study demonstrates a potential of the newly developed chemosensor for the detection of increased concentrations of H2S in insect cells and alive C.elegans.

• 出版日期2017-8
• 单位云南师范大学; 云南大学